Description

PKC-9 is a 2-(6-phenyl-1H indazol-3-yl)-1H-benzo[d]imidazole derivative optimized to be a  potent and selective inhibitor of protein kinase c-zeta (PKC-ζ; 5.18nM). The analog displays good selectivity over other PKC isoforms (α, βII, γ, δ, ε, μ, θ, η and ι/λ) and CDK-2. The inhibition of PKC-ζ is proposed to be a potential drug target for immune and inflammatory diseases.

Systematic Name:  4-(3-(4-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)-1H-indazol-6-yl)aniline

SMILES:  NC1=CC=C(C2=CC(NN=C3C4=NC5=C(C=CC=C5N6CCN(C)CC6)N4)=C3C=C2)C=C1

Formula: C25H25N7

Mol Wt: 423.52

PMID:  19097791

References

Trujillo JI, Kiefer JR, Huang W et al. 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor. Bioorg Med Chem Lett (2009); 19:908-11.

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