PIK-III, VPS34 inhibitor RGNCY-0041
Per 10 mg
PIK-III is a selective inhibitor of VPS34 that binds a unique hydrophobic pocket not present in related kinases such as PI(3)Kα. PIK-III acutely inhibits autophagy and de novo lipidation of LC3, and leads to the stabilization of autophagy substrates. VPS34 IC50 = 0.018μM.
Systematic Name: 4'-(cyclopropylmethyl)-N2-(pyridin-4-yl)-[4,5'-bipyrimidine]-2,2'-diamine
Molecular Weight: 319.37
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. Dowdle W.E, Nyfeler B., et al. Nature Cell Biology. 16(11):1069-1079 (2014).
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