RGNCY-0128 (Compound 15 PARP/PI3K inhibitor )

SOLD OUT!!  E-mail us at info@reagency.co if you are interested in this product.

Compound 15 is a novel potent dual PARP/PI3K inhibitor.  Compound 15 effectively inhibits PARP-1/2 and PI3K-alpha/delta with antiprolferative effects against both BRCA-deficient and BRCA-proficient cancer cells in cellular assays.  Compound 15 was shown to have a greater in vivo anti-tumor efficacy than the drug combination of Olaparib and BKM120 in the MDA-MB-468 xenograft mouse model with 74% inhibition without observable toxicity.  These data suggest that compound 15 is a potent dual PARP/PI3K inhibitor and may be an effective anti-cancer treatment.

Systematic Name:  N-(4-ethyl-3-(morpholinosulfonyl)phenyl)-3-(1H-pyrrol-1-yl)benzamide

SMILES:  O=S(N1CCOCC1)(C2=C(C)C=CC(NC(C3=CC(N4C=CC=C4)=CC=C3)=O)=C2)=O

Formula:   C23H25N3O4S

Mol Wt: 439.53