RGNCY-0126 (WG-449E TGF-Beta inhibitor)

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WG-449E is a potent TGF-Beta inhibitor that can down-regulate the mRNA and protein levels of collagen in hypertrophic scar-derived fibroblasts by inhibiting Smad2/3 phosphorylation.  WG-449E inhibited the proliferation, migration and contraction of fibroblasts in vitro and in vivo.  WG-449E also induced cell apoptosis by activating cleaved caspase3.  In the mechanical load-induced mouse mode, WG-449E reduced hypertrophic scar formation and collagen deposition indicating that it is a strong candidate for the treatment of hypertrophic scars.

Systematic Name: N,N-bis(2-methoxyethyl)-2-(2-phenylacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-8-carboxamide

SMILES:  O=C(N(CCOC)CCOC)C1=C(NC2=C3CCN(C(CC4=CC=CC=C4)=O)C2)C3=CC=C1

Formula:  C26H31N3O4

Mol Wt:  449.55