RGNCY-0113 (AC-73 CD147 inhibitor )

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AC-73 is a specific inhibitor of CD147 through disruption of CD147 dimerization.  AC-73 inhibts the invasion and motility of HCC cells but not HCC cells lacking the CD147 gene therb demonstrating on-target action.  It also reduces metastasis by by suppressing matrix metalloproteinases (MMP)-2 by down-regulating CD417/ERK1/2/signal tranducer and activator of transcription 3 (STAT3) signalling pathway.  AC-73 also attenuated the progression of liver metastasis in an orthotopic nude mouse model.  This suggests that AC-73 has potential use in HCC intervention.

Systematic Name:  3-(2-(([1,1'-biphenyl]-4-ylmethyl)amino)-1-hydroxyethyl)phenol

SMILES: OC1=CC=CC(C(CNCC2=CC=C(C3=CC=CC=C3)C=C2)O)=C1

Formula:  C21H21NO2

Mol Wt:  319.40

PMID:  26882566