RGNCY-0078 (8e LRRK2 inhibitor)

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Compound 8e is an inhibitor of leucine-rich repeat kinase 2 (LRRK2) which has been suggested as a therapeutic target for Parkinson's disease.  8e demonstrates a good in vitro and in vivo pharmacokinetic profile with high exposure in both brain and and blood (Br/Bl ratio 1:3).  This compound is orally bioavailable (F=91.6%) and highly tissue bound in mouse brain (99.7%).  8e is also highly selectivity across the kinome.

SMILE:  O=C(C1=C(OCC2=CC=C(F)C=C2)C=CC(C(F)(F)F)=C1)NC3=CC=CN=C3

Systematic Name:   2-((4-fluorobenzyl)oxy)-N-(pyridin-3-yl)-5-(trifluoromethyl)benzamide

Molecular Weight:  390.34

Formula:  C20H14F4N2O2

PMID:  28774425