RGNCY-0046 (AUTEN-67 MTMR14 inhibitor)

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AUTEN-67 is a specific inhibitor of MTMR14, a myotubularin-related phosphatase antagonizing the formation of autophagic membrane structures.  It significantly increases autophagic flux in cell lines and in vivo models. AUTEN-67 promotes longevity and protects neurons from undergoing stress-induced cell death. It also restores nesting behavior in a murine model of Alzheimer disease, Aging without apparent side effects. Therefore, AUTEN-67 can be used as a potent drug candidate to decelerate the aging process and counter various age-dependent degenerative diseases.

SMILES: COC1=CC2=C(N=CN=C2NC3=C(Cl)C=C(Cl)C=C3)C=C1OC

Systematic Name: N-(2,4-dichlorophenyl)-6,7-dimethoxyquinazolin-4-amine

Formula:  C16H13Cl2N3O2

PMID: 26312543

MWT: 474.45

Reference: Papp D, Kovacs T etal.  AUTEN-67, an autophagy-enhancing drug candidate with potent antiaging and neuroprotective effects.  Autophagy (2015). 27:[Epub ahead of print].

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