RGNCY-0017 (SGSM41 - Secretase Modulator)

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SGSM41 is an aminothiazole-bridged heterocycle-containing soluble c-secretase modulator (SGSM). It potently inhibits the production of toxic Ab42 (IC50 = 115nM ) and to a lesser degree Ab40 (IC50 = 1229nM), while concomitantly increasing the generation of shorter amyloid-β peptide species such as Ab38 and Ab37. This is a useful tool in the study of Alzheimer’s disease.

Systematic Name: N-(2-ethyl-4,5,6,7-tetrahydro-2H-indazol-3-yl)-4-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)thiazol-2-amine

SMILES: COC1=C(N2C=C(C)N=C2)C=CC(C3=CSC(NC4=C(CCCC5)C5=NN4CC)=N3)=C1

Molecular Weight: 434.56

Formula: C23H26N6OS

PMID: 25307057

Reference: Choi, Se Hoon, et al. "A three-dimensional human neural cell culture model of Alzheimer’s disease" Nature 515 (2014): 274–278

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