RGNCY-0011 (GPR35 Agonist)

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GPR35, an orphan rhodopsin-like class A G-protein coupled receptor. While some tyrosine metabolites, and lysophosphatidic acid species have been shown to activate GPR35, the physiological effects of this are far from fully understood, though there is a growing body of evidence to suggest it is important in blood pressure regulation. RGNCY-0011 an exceptionally potent GPR35 agonist (EC50 = 4.45 nM).
SMILES: C(C1=CC(C2=CC(Br)=CC(NC(C3=C(F)C=C(OC)C=C3F)=O)=C2O1)=O)=O

Systematic Name: 6-bromo-8-(2,6-difluoro-4-methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic acid

Formula: C18H10BrF2NO6

Molecular Weight: 454.18

PMID: 23888932

Reference: Thimm, Dominik, et al. "6-Bromo-8-(4-[3H] methoxybenzamido)-4-oxo-4 H-chromene-2-carboxylic Acid: A Powerful Tool for Studying Orphan G Protein-Coupled Receptor GPR35." Journal of Medicinal Chemistry 56.17 (2013): 7084-7099.


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Tags: RGNCY-0011, GPR35, Blood pressure