RGNCY-0007 (BMS819881, MCHR1 antagonist)

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BMS-819881 is a MCHR1 (Melanin Concentrating Hormone Receptor 1) antagonist with minimal hERG activity, with potential as an anti-obesity drug. Currently in Phase 1 clinical trial as the phosphate ester pro-drug.



SMILES: COC1=CC(N2C=NC3=C(SC(C4=CC=C(Cl)C=C4)=C3)C2=O)=CC=C1OC[C@H](O)C5CC5

Systematic Name: R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

Molecular Weight: 468.95

Formula: C24H21ClN2O4S

PMID: 25165888

Reference: Washburn, William N., et al. "Identification of a non-basic melanin hormone receptor 1 antagonist as an anti-obesity clinical candidate." Journal of Medicinal Chemistry 57.18 (2014): 7509–7522.

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Tags: RGNCY-0007, BMS819881, MCHR1, Melanin