FCY-302 Apoptosis inducer (RGNCY-0123)
Per 10 mg
FCY-302 is a novel inducer of apoptosis in leukemia and myeloma cells. FCY-302 selectively inhibited the proliferation of cancer cell lines, RPMI-8226, Jurkat and HL-60 by 8-, 9- and 13-fold more compared to normal Vero cells. FCY-302 decreased the anti-apoptotic Bcl-2 levels and increased pro-apoptotic Bax proteins in leukemia and myeloma cell lines. Results suggest that FCY-302 inhibited the proliferation of leukemia and myeloma cancer cells by altering key mitochondrial and antioxidant enzymes driving them to apoptosis.
Systematic Name: (E)-2-benzylidene-4-isopropyl-7-methyl-2,3-dihydro-1H-inden-1-one
Mol Wt: 276.38
Rajagopalan P, et al. FCY-302, a Novel Small Molecule, Induces Apoptosis in Leukemia and Myeloma
Cells by Attenuating Key Antioxidant and Mitochondrial Enzymes. Oncol Res. 2019 Aug 8;27(8):957-964. doi: 10.3727/096504019X15555428221646. Epub 2019 Apr 17.
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