6Br-6a STAT3 inhibitor (RGNCY-0122)
Per 10 mg
6Br-6a is a novel STAT3 inhibitor. Stat3 protein is overexpressed in many malignancies yet there is no STAT3 inhibitor used clinically. 6Br-6a was shown to induce cell cycle arrest and apoptosis (by regulating cyclin D1 and Bcl-2) in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro and in vivo in xenograft mouse models with effective tumor inhibition. 6Br-6a may be a potential candidate for the treatment of breast cancer.
Systematic Name: (E)-1-(4-(4-bromo-1,1-dioxidocinnamoyl)piperazin-1-yl)-3-(3,4-dimethoxyphenyl)prop-2-en-1-one
Mol Wt: 547.42
Liu Z, et al. Small molecule STAT3 inhibitor, 6Br-6a suppresses breast cancer growth in vitro and in vivo. Biomedicine & Pharmacotherapy 121 (2020) 109502.
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