CS-11 PP2A–β-Catenin inhibitor RGNCY-0096
Per 10 mg
CS-11 is a novel inhibitor of PP2A–β-Catenin signalling that limits both in vivo tumor growth and metastases. By inhibiting PP2A and β-Catenin interaction, Cs-11diminishes the expression of active β-Catenin and its target proteins c-Myc and Cyclin D1. It also promotes E-Cadherin upregulation on the cell surface and increases β-Catenin and E-Cadherin association that may prevent metastases.
Systematic Name: 2-((E)-2-hydroxy-3-isopropyl-5-((E)-3-oxo-3-(p-tolyl)prop-1-en-1-yl)benzylidene)-N-phenylhydrazine-1-carboxamide
Mol Wt: 441.53
Discovery of a Novel Small-Molecule Inhibitor that Targets PP2A–β-Catenin Signaling and RestrictsTumor Growth and Metastasis. Maheshwari S. etal. Mol Cancer Ther. 2017 Sep;16(9):1791-1805. doi: 10.1158/1535-7163.MCT-16-0584. Epub 2017 May 12.
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