NCO-141 SIRT2 inhibitor RGNCY-0095
Per 10 mg
NCO-141 is a novel specific inhibitor of SIRT2. It inhibited cell growth of leukemic cell lines including HTLV-1-transformed T-cells . NCO-141 induced apoptosis by caspase activation and mitochondrial superoxide generation in leukemic cell lines which was not prevented by a caspase inhibitor. NCO-141 increased the LC3-II level with autophagosome accumulation suggesting autophagic cell death. Therefore,NCO-141 caused apoptosis and autophagy simultaneously. These data suggest that NCO-141 is highly effective against leukemic cells in caspase-dependent or -independent manners via autophagy and may have therapeutic potential for leukemias such as ALL. IC50 = 0.5µM
Systematic Name: 2-(1-aminovinyl)-N-(3-(3-fluorophenethoxy)phenyl)aniline
Molecular Weight: 348.42
Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines. Kozako, T et al. BMC Cancer (2018) 18:791.
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