ULK-101 Autophagy inhibitor RGNCY-0090
Per 10 mg
ULK-101 is a selective and potent inhibitor of autophagy. ULK-101 suppresses autophagy induction and autophagic flux in response to a variety of stimuli. ULK-101 inhibition is able to sensitize KRAS mutant lung cancer cells to nutrient stress. ULK-101 is a promising target for autophagy inhibition due to its central role in in pathway activation, druggability and selectivity for autophagy. ULK1 inhibition IC50 = 8.3nM.
Systematic Name: (S)-N-(1-cyclopropyl-2,2,2-trifluoroethyl)-4-(6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide
Molecular Weight: 460.45
A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient
Stress. Martin, KR et al. iScience 8, 74–84, October 26, 2018.
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